However, it was not unexpected to find that erastin-induced PCa DEGs were involved in the regulation of cell death, cellular response to reactive oxygen species, fatty acid biosynthetic process, activation of the MAPK activity pathway, intrinsic apoptotic signaling pathway in response to DNA damage by the P53 class mediator and cellular amino acid metabolic process in LNCaP (Fig. 4a) and PC3 cells (Fig. 4b). Here, TP53 is linked to posterior cortical atrophy.