CLU and breast cancer: Our results also indicated that FRGs such as NRXN3, CLU, and UNC5B showed different expression levels between PCa and normal tissue, and their expression patterns were positively related to GPX4 and SLC7A11. NRXN3 has impacts on various functions of cancer, such as regulating the metastasis of nasopharyngeal carcinoma [28], inhibiting the proliferation and migration of glioma [29], and affecting the risk of breast cancer development [30].