Our study was the first to reveal the differential expression of NRXN3 between PCa tissue and normal tissue, and to examine the ferroptotic impact of PCa cells through the regulation of NRXN3. Furthermore, CLU causes ATP degradation, which results in peroxidation in cells [32], while the upregulation of CLU inhibits PCa cell death [33]. This evidence concerns the gene NRXN3 and posterior cortical atrophy.