We detected Gde2 expression in major brain areas including the thalamus (Th) and caudate putamen (CP) (Fig. 1A, B), with particularly strong expression in the medial habenula and the medial and anterior amygdala (Fig. 1C–F), which are areas associated with regulation of emotional and motivational aspects of behavior including fear/anxiety responses [33, 34]. Here, GDPD5 is linked to Anxiety.