MAPT and Alzheimer disease: As expected, AT180 staining in JNPL3 mice and AD brain was characterized by intense perinuclear staining confined to a subset of isolated cells in hippocampus and cortex (Sup Fig. 4E-H); a similar pattern was observed in CatD-KO brains, with a subset of neuronal cells, including dentate gyrus mossy cells, showing intense perinuclear AT180-immunoreactivity, albeit on a background of relatively ubiquitous phospho-tau staining (Sup.