Moreover, the finding that tau pathology was entirely absent from a mouse model of a different lysosomal disease, Krabbe A, one that also suffers premature lethality, lends strong support to the idea that these changes are specific to CatD deficiency and not attributable to non-specific effects of lysosomal dysfunction or antemortem agonal conditions. The gene discussed is MAPT; the disease is Lysosomal disease.