ABCA3 and Hermansky-Pudlak syndrome: Similarly, numerous genes play roles in lung development, such as ABCA3. The AP3B1 gene encodes the β3A subunit of the adaptor protein complex 3 (AP-3), and mutations in the AP3B1 gene result in Hermansky-Pudlak syndrome (HPS) subtypes HPS-2 and HPS-10 [87].