The authors of this study also generated SSTCre-Grm5−/− mice to confirm that mGlu5 on SST+ INs mediates restraint stress-induced changes in mPFC physiology, and reported that the loss of mGlu5 in SST+ neurons prevented stress-induced behavioral adaptations, but did not change baseline anxiety-like behavior [81]. The gene discussed is GRM5; the disease is Anxiety.