5-LO products dose-dependently stimulate myeloid stem cell proliferation [72] and a mouse model of BCR-ABL-induced CML could show that absence of 5-LO prevents CML induction by BCR-ABL due to a defect in leukemic stem cell differentiation, division and long-term survival. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.