In keeping with this, we could show that pharmacological inhibition of 5-LO also affects the aberrant stem cell capacity in a PML/RARα-positive model of AML (acute myeloid leukemia) and a murine cancer stem cell (CSC) model [Sca-1(+)/lin(−) murine hematopoietic stem and progenitor cells retrovirally transduced with PML/RARα]. This evidence concerns the gene RARA and acute myeloid leukemia.