SEMA3F and obesity due to melanocortin 4 receptor deficiency: We repeated these analyses using the common BMI-associated variant (rs9843653) at BSN and identified 23 associated proteins, the most significant of which was semaphorin-3F (−0.03 s.d. per BMI-increasing allele, P = 6.7 × 10−45), a member of the semaphorin family that has been previously implicated in obesity etiology25.