We first investigated in details the distribution of CD34+lin-HSPCs in a cohort of MDS and non-MDS samples (cohort #1 in Supplementary Table 1) using a panel of 19 antibodies (combination #1 in Supplementary Table 2) allowing the identification of CD34+HSPCs sub-populations among both CD38- and CD38+ fractions of cells. The gene discussed is CD38; the disease is myelodysplastic syndrome.