The CNs within each CNC are enriched with different types of infiltrating immune cells, which we named with ascending tumor content as: CD4-rich (33% tumor), CD68−CD163+ mac-rich (38%), DC-rich (40%), CD8-rich (44%), Treg-rich (53%), Dual-positive (CD68+CD163+) mac-rich (60%), CD68+CD163− mac-rich (67%), and tumor-rich (87%). The gene discussed is CD68; the disease is neoplasm.