HLA-DRB1 and Behcet disease: A worldwide meta-analysis investigating the link between BD and variations in genes of both HLA Class I (A, B, and C) and Class II (DRB1, DQB1, and DPB1) has confirmed that the HLA-B ∗ 51;Cw ∗ 15 and HLA-B ∗ 51;Cw ∗ 14 haplotypes were the second and third most frequent haplotypes, respectively, while the HLA-B ∗ 51; Cw ∗ 16 haplotype was in sixth place32.