Given that MCL1 is a pro-survival Bcl-2-like protein, and gossypol-induced MCL1 links to the less efficacy of gossypol, we found combination of gossypol with MCL1 inhibitor S63845 indeed achieve a better growth inhibition of cancer cells.467 However, the underlying mechanism for gossypol to selectively cause accumulation of MCL1 and NOXA, but not other substrates of CRL1 and CRL5, is a subject for future investigation. Here, PMAIP1 is linked to cancer.