CDT1 and acute myeloid leukemia: By inactivation of CRL1SKP2 and CRL4CDT2, MLN4924 causes the accumulation of their substrate CDT1 to induce DNA re-replication and subsequent cell apoptosis in HCT-116 cells.365 By inactivating CRL1β-TrCP, IκBα is accumulated to block NF-κB activation, leading to apoptosis induction in ABC lymphoma and AML cells.349,350,375 Also in AML cells, inactivation of NF-κB transcriptionally downregulates miR-155 via decreasing NF-κB and binding to the miR-155 promoter.