UBE2F and lung cancer: The same virtual screening also identified a small molecule HA-9104, which selectively targets the UBE2F-CRL5 axis.449 Specifically, HA-9104 binds to UBE2F, and blocks CUL5 neddylation to cause accumulation of CRL5 substrate NOXA, resulting in induction of apoptosis in lung cancer cells both in vitro cell culture setting and in vivo xenograft model.449 Medicinal chemistry-based SAR (Structure and Activity Relationship) study is under the way to optimize anticancer activity of these compounds.