MDM2 and liver cancer: Neddylation-activated CRL2 E3 ligase targets RhoB for ubiquitylation and degradation, as a key molecular event that drives liver carcinogenesis.335 The master lipogenic transcription factor SREBP-1 is also subjected to UBE2M-mediated neddylation, and SREBP-1 neddylation leads to its stabilization, which is related to progression of liver cancer.325 Likewise, the oncoprotein Hu antigen R (HuR) is stabilized by Mdm2-mediated neddylation, which contributes to liver cancer metastases.330