We infected DaNs derived from a PD patient carrying an A53T mutation in α-Syn [34] as well as its isogenic control with lentiviruses carrying Cas9/sgRNAs against CDK14. Neurons infected with sgRNAs targeting either exon 3 (E3) or exon 8 (E8) of CDK14, exhibited approximately 50% of the CDK14 levels of the control cultures (Fig. 3). Here, CDK14 is linked to Parkinson disease.