CD8A and inflammatory bowel disease: To this end, CD44lo CD8+ TN cells from C57BL/6 (Ly5.1) mice were sorted into CD5loLy6C−, CD5hiLy6C−, and CD5hiLy6C+ cells (hereafter, referred to as CD5lo, Ly6C−, and Ly6C+ cells, respectively; Supplementary Fig. 1a) and were adoptively transferred to Rag1−/− mice (Ly5.2) to induce T cell-mediated IBD (Fig. 1a).