MLN and inflammatory bowel disease: Notably, despite such a defect in inducing IBD, the ability of the Ccr6−/− CD5lo subset to produce IL-17 was still remarkably high, as evidenced by the enhanced frequencies (albeit not numbers) of IL-17A-producing cells in the Ccr6−/− CD5lo subset compared with that in the Ccr6−/− Ly6C− and Ly6C+ subsets in the day 14 LI (Fig. 3e and Supplementary Fig. 3d−f) and mLN (Supplementary Fig. 3g−j).