DHODH and cancer: Since DHODH is a critical suppressor of ferroptosis through reducing ubiquinone (CoQ) to ubiquinol (CoQH2) [14, 26, 27], we wondered whether POLQ is involved in suppressing ferroptosis, we systematically interrogated the Cancer Therapeutics Response Portal datasets, we found that POLQ expression correlated with resistance to ferroptosis inducers ((RSL3, ML210 and ML162, which inhibit GPX4 activity) (Fig. 3A).