PTPRC and neoplasm: To further evaluate the proliferation potential and immunomodulatory role of CD45-overexpressing tumor cells in vivo, we transfected CT26 cells with vectors encoding mouse CD45 proteins and compared the tumorigenic ability of CT26-Vector cells and CT26-CD45 cells in immunocompetent Balb/C mice or immunodeficient Balb/C nude mice (Fig. 5a).