SLC32A1 and epilepsy: Spontaneous epilepsy-sensitizing mutations have been characterized in other mouse lines (Yang et al., 2003), and a similar Vgat-Cre line has been found to exhibit reduced Vgat mRNA and protein, with enhanced kindling epileptogenesis, suggesting that creation of the cre-line disrupted the endogenous Vgat gene (Straub et al., 2020).