As for KEGG pathways, ACTN1, TLN1, F5 and WAS were mainly enriched in immune-related pathways, such as chemokine signaling pathway, B cell receptor signaling pathway, Fc gamma R-mediated phagocytosis, antigen processing and presentation (Figure 10A–10D), while JMJD1C was more likely participated in pathways related to neuroinflammation, such as Alzheimer’s disease, Huntington’s disease and oxidative phosphorylation (Figure 10E). The gene discussed is F5; the disease is early-onset autosomal dominant Alzheimer disease.