Further analysis assessing interactions between oxysterols and APOE revealed lower risk of dementia (fully adjusted HR = 0.02 [CI:0.00‐0.71], p = 0.02) and cognitive impairment (fully adjusted HR = 0.04 [CI:0.00‐0.78], p = 0.03) in relation to higher 24‐OHC/27‐OHC in APOE2+ compared to APOE3 carriers (Table 4; Figure A6 in Appendix A). This evidence concerns the gene APOE and dementia.