SPRED2 and type 2 diabetes mellitus: Of the 20 FDR 25% tested T2D-DMPs, 9 sites (in OTX2, SPRED2, SLC16A3, B3GAT2, METTL26, TNIP1, TXNIP, MMP15 and an intergenic regions) had significant associations in the T2D-discordant MZ twin analysis after multiple testing correction (Supplementary Table S1).