Of the 20 FDR 25% T2D-DMPs reported in this study 19 are previously unreported and only the 450 k CpG site in TXNIP (cg19693031; 1.1 kb away from MCC-seq T2D-DMP chr1:145440435-145440436) has been robustly replicated in previous studies. Here, TXNIP is linked to type 2 diabetes mellitus.