SPRED2 and type 1 diabetes mellitus: We found GWAS links between 7 T2D-DMP genes and T2D or related phenotypes (Fig. 3b), including SPRED2 (T2D), ITPR1 and PLD6 (Diabetic complications), SLC16A3 (BMI), TCF7 (Type 1 Diabetes), RGL3 (blood pressure) and TNIP1 (autoimmune traits).