Genes linked to T2D complications or comorbidities include FSCN1, ITPR1, B3GAT2 and PLD6. There is a positive association between diabetes and a number of cancers76 and we observed differential methylation in the transcription start site of FSCN1, which has been shown to be upregulated in cancer.77 This evidence concerns the gene PLD6 and type 2 diabetes mellitus.