ANGPTL4 and obstructive sleep apnea syndrome: To further investigate the impact of ANGPTL4 genetic variants on lipid profiles in 4455 OSA subjects (678 non-OSA, 894 moderate OSA, and 2883 severe OSA), we analyzed the clinical (anthropometric, biochemical phenotypes, and sleep parameters) characteristics of ANGPTL4 T266M recessive models across different OSA severities using a nonparametric test (Supplementary Table S2).