THPO and Thrombocytopenia: To confirm the in vivo therapeutic influence of VLZ on thrombocytopenia, a thrombocytopenia mouse model was constructed by 4 Gy X-ray total body irradiation, and KM mice were administered VLZ (2.5 mg/kg, 5 mg/kg, and 10 mg/kg) and rhTPO (recombinant human thrombopoietin, 3000 U/kg) for 12 days after radiation (Figure 4a).