(A) Representative H&E staining of pancreatic tumor sections derived from KPC cells of the indicated genotypes, SMAD4 KO (n=12), SMAD4/STAT3 DKO (n=3) and TGFBR2/STAT3 DKO (n=3), where n denotes the number of mice injected. The gene discussed is SMAD4; the disease is pancreatic neoplasm.