Immunocompetent patients demonstrated a biomarker profile in nonsurvivors over the first 7 days of ARDS that was similar to what was seen in the entire cohort (Supplemental Figure 7), with elevations in all biomarker classes, but with the highest levels (highest adjusted β coefficients) in tissue injury markers (ANG2 and sRAGE) and in DAMPs. This evidence concerns the gene ANGPT2 and acute respiratory distress syndrome.