Furthermore, 5-HT1R signaling regulatesthe mammalian target of rapamycin (mTOR) and mediates extracellular-signalregulated kinase/mitogen-activated protein kinase (ERK/MAPK) signalingto modulate nuclear factor “kappa-light-chain-enhancer”of activated B-cells (NF-kB).98−100 Changes in 5-HT1R-mediated signalinghave been associated with anxiety and depressive disorders.101 These in turn are risk factors for cardiovasculardiseases.102. This evidence concerns the gene MTOR and depressive disorder.