At Bonferroni significance (p < 3.25 × 10−5), the MR analysis revealed 11 significantly associated protein‐allergic diseases pairs (Table 1, Figure 2), namely, Interleukin‐6 receptor (IL6R), Interleukin‐1 receptor (IL1R1), TNF alpha induced protein 3 (TNFAIP3), Erb‐b2 receptor tyrosine kinase 3 (ERBB3), Inositol‐trisphosphate 3‐kinase A (ITPKA), Interleukin 1 receptor‐like 1 (IL1RL1), Toll‐like receptor 1 (TLR1), Kynureninase (KYNU), Layilin (LAYN), LDL receptor related protein 11 (LRP11), Interleukin 1 receptor like 2 (IL1RL2). The gene discussed is IL1RL2; the disease is allergic disease.