In summary, our comprehensive analysis indicates a causal relationship between genetically determined circulating levels of TNFAIP3, LAYN, IL6R, TLR1, IL1R1, IL1RL2, ERBB3, LRP11, KYNU, ITPKA, and IL1RL1 and the risk of allergic diseases. The gene discussed is IL1R1; the disease is allergic disease.