Firstly, we conducted reverse MR analysis, and the results indicated that there were no causal effects of allergic diseases on the levels of 10 identified proteins, including IL6R, IL1R1, TNFAIP3, ERBB3, ITPKA, IL1RL1, TLR1, KYNU, LAYN and LRP11. This evidence concerns the gene IL1RL1 and allergic disease.