were not significantly different comparing the HO and WT samples from within either genetic background (i.e., 3xTg‐AD HO vs. 3xTg‐AD WT, or hAβ‐KI HO vs. hAβ‐KI WT), or comparing the hAβ‐KI WT mice to the 3xTg‐AD WT mice. The gene discussed is HMOX1; the disease is Alzheimer disease.