Furthermore, the overexpression of SIRT3 by LV‐SIRT3 reversed diabetes‐induced hypersensitivity to mechanical and thermal stimulation (Figure 3I,J), and neuronal hyperexcitability in medium–small‐sized neurons, shown as a significant decrease in the number of AP, an increase in the ISI, AHP 80% duration, AP amplitude, AHP amplitude, and TP (Figure 3K–O). Here, SIRT3 is linked to diabetes mellitus.