G-quadruplex forming sequences are enriched in Alzheimer's aggregates (107) and several aggregation-prone proteins underlying ALS including hnRNP family proteins (108), FUS (109), TDP-43 (110), Ewing's sarcoma protein (111) and TIA1, are shown to bind G-quadruplexes (33). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.