EFEMP1 and hypothyroidism: Our findings indicated that ECM1 is linked to osteoarthrosis and other arthropathies; EFEMP1 is associated with conditions such as inguinal hernia and diverticulitis, ISLR2 with abdominal hernia, MST1 with hypovolemia and heartburn, USP8 with unspecified monoarthritis, and PSMB4 with hypothyroidism (refer to eFigures 3 and 4 in Appendix S2; p < 0.05/1402 = 3.57e−5).