DRD1 and glioblastoma: In glioblastoma (GBM), DRD1 expression is associated with a more favorable prognosis [27], and one study found that DRD1 agonism inhibited cell growth through disrupting autophagic flux and showed that the DRD1 agonist SKF83959 and the chemotherapeutic temozolomide have a synergistic antitumor effect [27].