IGLON5 and Creutzfeldt Jacob disease: This is an intriguing association as both conditions have been associated with brain deposits of phosphorylated tau protein.<h4>Conclusion</h4>IgLON5 Abs may be observed in patients with a diagnosis of CJD; it is unknown whether a synergistic effect of IgLON5 Abs with CJD exists, increasing neurodegenerative changes.