In the group of patients with CHD and obesity, mtDNA copy number correlated with basal TNF-α secretion (R = 0.465, р = 0.001) as well as with LPS-stimulated secretion (R = 0.591, р<0.001), and TNF-α secretion after the second LPS-stimulation (R = 0.353, р = 0.024). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.