TNF and obesity due to melanocortin 4 receptor deficiency: However, the study results indicate the impact of increased mtDNA copy number on inflammatory activation of monocytes, which is expressed in excess TNF-α secretion, in patients with CHD and obesity so the further study investigating a number of parameters of mitochondrial functions on a larger cohort should be planned to evaluate the association of mitochondrial dysfunction and violation of inflammatory response of innate immune cells.