APP/PS1 transgenic mice are an internationally recognized mice model for AD, and display the core pathological processes found in AD, including neuroinflammatory plaques, which mainly are induced by microglial activation, and exhibit both cognitive behavioral impairments and neuropsychiatric disorders relevant to AD, including memory loss, hyperlocomotion, anxiety-like behavior and depression-like behavior. The gene discussed is APP; the disease is Alzheimer disease.