Recently, we observed the ability of TSA, to reverse the hypoacetylation of histone H4 (H4K12) in the hippocampus and increase albumin expression and Aβ clearance, as well as ameliorate Alzheimer’s disease-related pathology and cognitive deficits in APP/PS1 mice (Su et al., 2021). The gene discussed is APP; the disease is Cognitive impairment.