Studies have shown that TSA reverses anxiety-like symptoms and memory impairments induced by maternal binge alcohol drinking in mice (Montagud-Romero et al., 2019), and also involved in the regulation of central 5-HT1A receptor expression (Zhu et al., 2021) and BNDF expression (Montagud-Romero et al., 2019) associated with adjustment of anxiety- and depressive-related behaviors. The gene discussed is HTR1A; the disease is Anxiety.