NFKB1 and neoplasm: RES dramatically reduced the activation of tumor-promoting factors (NF-κB, MMP-9, CXCR4) and epithelial-to-mesenchymal transition-factors (increased vimentin and slug, decreased E-cadherin) in TNF-induced activation of CRC cells by preventing EMT and CSC formation (Buhrmann et al., 2018).