Because autophagy is inhibited in human bone marrow CD138 primary myeloma cells and multiple myeloma (MM) cell lines, LYC-induced proteasomal degradation of HMGB1 inhibits the activation of the MEK-ERK signaling pathway and Bcl-2 phosphorylation declines, leading to the constitutive association of Bcl-2 with Beclin-1 (Roy et al., 2016). The gene discussed is BECN1; the disease is plasma cell myeloma.