Th ABC transporters play important roles in mediating the efflux of drugs and metabolites from the NVU cells and have been shown to contribute to AD progression due to involvement in the clearance of Aβ from the brain (Xiong et al., 2009; Bernstein et al., 2014; Pahnke et al., 2014; Pereira et al., 2018). The gene discussed is ABCG2; the disease is Alzheimer disease.