Studies have demonstrated that from total genetic aberration, about 70%–80% of uterine leiomyoma’s shown site-specific somatic mutation on mediator complex subunit 12 (MED12) genes in different populations, including Finnish (Caucasian), northern United States regions, and South African women (Mittal et al., 2015; Noutakdie Tochie et al., 2021). This evidence concerns the gene MED12 and Uterine leiomyoma.