Further, it is also reported that genetic alterations that result in HMGA2 over-expression, disruption of the COL4A5-COL4A6 locus, and biallelic loss of FH, which encodes the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase are associated with uterine leiomyoma (Tomlinson et al., 2002; Kämpjärvi et al., 2014; Pandey et al., 2024). The gene discussed is FH; the disease is Uterine leiomyoma.