EBV infection of host cells produces a protein, latent membrane protein 1 (LMP1), LMP1 promotes the expression and activity of DNMT1, 3A and 3B, induces hypermethylation of the CDH1 promoter and down-regulation of calreticulin 1, as well as hypermethylation of the RASSF10 tumor suppressor gene, which in turn promotes tumorigenesis (Pietropaolo et al., 2021) (Figure 1). Here, PDLIM7 is linked to Epstein-Barr virus infection.