These viral miRNAs can interfere with the expression of genes involved in cell cycle control, apoptosis, and immune responses, thereby promoting tumor formation (Bartel, 2009; Xiao and Rajewsky, 2009).It is known that Kaposi’s sarcoma-associated herpesvirus (KSHV) produces a series of miRNAs; one of them, (miR-K1) downregulated the expression of several tumor suppressor genes, including p21 (Gottwein and Cullen, 2010), leading to uncontrolled cell growth and the development of Kaposi’s sarcoma and other KSHV-associated malignancies (Figure 1). Here, CDKN1A is linked to neoplasm.