TLN1 and Loeys-Dietz syndrome: Variants in genes associated with thoracic aortic aneurysm and dissection (TAAD), Loeys-Dietz syndrome (SMAD2), vascular Ehlers-Danlos syndrome (COL3A1), familial thoracic aortic aneurysm and dissection (LOX), and the cytoskeletal protein talin 1 (TLN) have been reported to have increased prevalence in cohorts of SCAD patients (46, 60).