In a mouse model of HFD-induced NAFLD, supplementation with B. uniformis significantly downregulated the expression of hepatic lipogenesis-related proteins, such as SREBP-1, ChREBP, ACC, FAS, and leptin; thereby alleviating the progression of NAFLD (Lee et al., 2021). This evidence concerns the gene SREBF1 and metabolic dysfunction-associated steatotic liver disease.