To investigate the contribution of individual ADAM to HIV-1 infection, we infected CD8-depleted PBMC with a replication competent R5 tropic HIV-1BAL in the presence of either ADAM10 or 17 specific or broad specificity inhibitors and analyzed the intracellular p24 levels on day 7 of post infections (Figure 3). The gene discussed is CD8A; the disease is HIV-1 infection.