CCL2 and early-onset autosomal dominant Alzheimer disease: Furthermore, an example describing inflammation and inflammatory mediators’ role in Alzheimer’s disease is the effect of Aγ-stimulated signaling pathways with Aγ aggregate production, and their corresponding inflammatory cytokine release as interleukin (IL)-1γ, IL-6, and TNF-α, acute phase proteins, chemokines as chemokine (C-C motif) ligand 2 (CCL2), and reactive nitrogen species (RNS) and reactive oxygen species (ROS).