PAFAH1B1 and classic lissencephaly: The regulatory PAF-AH β-subunit, the LIS1 protein, was shown to be an essential regulator of neural progenitors' cell proliferation and migration (Jheng et al., 2018; Rolland et al., 2021; Penisson et al., 2022) since the LIS1 mutation causes severe brain development impairment and was determined to be the main cause of type 1 lissencephaly (Hines et al., 2018).