It is possible that while precluding detection of a significant restoration of SRF phosphorylation in whole tissue extracts, AAV9sc.PBD improved SRF phosphorylation and cardiac function following threshold delivery to a subset of ventricular myocytes, similar to the beneficial effects of partial dystrophin restoration in Duchenne’s muscular dystrophy.19 This evidence concerns the gene SRF and Duchenne muscular dystrophy.