The well-characterized Tpm1 E54K DCM mouse model [FVB/N-Tg(Myh6-Tpm1∗E54K), abbreviated “TM54”] is a transgenic in which the indicated α-tropomyosin missense mutant is expressed under the control of the cardiac myocyte-specific α-myosin heavy chain promoter, resulting in replacement of wild-type myocardial α-tropomyosin with E54K mutant protein.12 Here, MYH6 is linked to familial dilated cardiomyopathy.