mRNA levels for Atp2a2, which encodes sarco(endo)plasmic reticulum calcium-ATPase 2 pump (SERCA2) and is typically down-regulated in heart failure,14 were decreased in TM54 AAV9sc.GFP control mice, but restored in AAV9sc.PBD-treated mice. This evidence concerns the gene ATP2A2 and heart failure.