NPPB and Myocardial fibrosis: In addition, Tgfb2 (transforming growth factor β2), which promotes myocardial fibrosis and hypertrophy, and Nppa (atrial natriuretic peptide) and Nppb (brain natriuretic peptide), which are markers of cardiac stress,17 were increased in expression in TM54 AAV9sc.GFP control mice and significantly reduced toward control NTG levels in AAV9sc.PBD-treated TM54 mice.