WME method did not detect IL-12p70 (OR, 1.073; 95% CI, 0.990–1.162; P = 0.086), IL-13 (OR, 1.059; 95% CI, 0.9866–1.136, P = 0.115), IFN-γ (OR, 1.106; 95% CI, 0.935–1.308; P = 0.239), MCP-1 (OR, 0.917; 95% CI, 0.823–1.021; P = 0.113), TNF-α (OR, 0.887; 95% CI, 0.7855–1.003; P = 0.056) had a significant effect on the risk of HD, but the direction of effect was consistent with that of IVW (Table 2; Supplementary Figure 2). The gene discussed is TNF; the disease is Huntington disease.