It is interesting to note that the motif SL%LNTE was also enriched in atherosclerosis-related human cytotoxic CD4+T cells reported in another recent study (39) wherein we reported the pathogenic conversion of human regulatory (Treg) cells into inflammatory and cytotoxic exTreg cells under conditions of chronic maladaptive inflammation, as found in CVD. This evidence concerns the gene CD4 and atherosclerosis.