However, while some subjects showed a trend for increasing S protein-specific CD8+ T cell frequencies after each antigen exposure (i.e., infection or booster vaccination), no significant differences in the frequencies of S protein-specific CD8+ T cells were found at any time point (excluding comparisons to the pre-vaccination time point, p>0.05, Dunn’s corrected Kruskal-Wallis test). The gene discussed is CD8A; the disease is infection.