NFKB1 and cancer: Next, we investigated the impact of potential interactions between cancer signature pathways and TLS-derived subtypes on patients and found that some pathways such as HALLMARK_UV_RESPONSE_UP, HALLMARK_ESTROGEN_RESPONSE_EARLY, and other signature signaling pathways had lower activity levels in Cluster 3 (Supplementary Table S5), may be positively correlated with survival, while HALLMARK_KRAS_SIGNALING_UP, HALLMARK_APOPTOSIS, HALLMARK_TNFA_SIGNALING_VIA_NFKB, and other signature signaling pathways were more active in Cluster 3, may be negatively correlated with survival (Figure 3B).