The KM survival curves showed that CD46, JAG1, IL6, and IL6R were all risk factors that lead to poor prognosis in breast cancer patients (Figure 5K), which implies that the enhanced interaction between CD46-JAG1 leads to poor prognosis in breast cancer patients, along with the IL6-(IL6R+IL6ST) axis. The gene discussed is JAG1; the disease is breast carcinoma.