Prototypic diseases are hereditary periodic fever syndromes, such as Familial Mediterranean fever (FMF, OMIM#249100), Cryopyrin-associated periodic syndrome (CAPS, OMIM# 606416), TNF receptor associated periodic syndrome (TRAPS, OMIM # 142680), Hyper IgD syndrome (HIDS, OMIM#260920), and NLRP12 autoinflammatory disease (OMIM#611762); all are autosomal recessive or dominant disorders.[3] SAIDs also include Nucleotide-binding oligomerization domain containing protein 2 (NOD2)-associated diseases like Blau syndrome (OMIM# 186580), Crohn’s disease and Yao syndrome (YAOS, OMIM# 617321).[3]. Here, NOD2 is linked to Crohn disease.