For example, glycolysis promotes skeletal muscle cell pyroptosis by activating the NLRP3 inflammasome in DM.[29] Since autoantibodies against anti-TIF-1-γ, a member of the tripartite motif (TRIM) proteins, has a strong association with DM related malignancy, certain TRIM member genes are found to be upregulated. This evidence concerns the gene NLRP3 and dermatomyositis.