CD40LG and rheumatoid arthritis: During the last decade, multiple antibodies have been identified in RA against the citrullinated peptides including IgG, IgA, IgM.[3] Anti-CCP has been emerging as a highly specific marker in RA diagnosis and prognosis.[4] Both tests are sensitive; however, anti-CCP is more specific for RA diagnosis.[5] The presence of RF positivity or anti-CCP is incorporated and weighed in the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for RA.[6]