The RCAS-mediated expression of either YAP1-MAML2 (found in a subset of pediatric NF2 wild-type meningiomas) or S127/397A-YAP1 (a constitutively active form of YAP1 that mimics functional NF2 loss) in Nestin-positive cells in the meninges of Cdkn2a null new-born mouse pups resulted in the formation of high-grade meningioma-like tumors in 68 and 97% of mice, respectively, with a latency of 80–150 days. Here, NF2 is linked to meningioma.