NF2/Merlin is a tumor suppressor and upstream regulator of the Hippo Signaling pathway that translates mechanical stimuli into transcriptional signals through a cascade of serine-threonine kinases that ultimately phosphorylate and inhibit the functions of the transcriptional coactivator YAP1 (Yes-associated protein 1, and its paralog TAZ) (15–19). This evidence concerns the gene NF2 and neoplasm.