PTEN and anaplastic meningioma: Frequently mutated genes in high-grade meningiomas include CDKN2A (mutated in 4% of atypical and 28% of anaplastic meningiomas), TERT promoter mutations (14 to 23% of WHO grade 3 meningiomas), ARID1A (5.4%), PTEN (4.3% and frequent loss of chromosome 10q harboring PTEN), KDM6A (3.5%), SUFU (2.7%), and TP53 (2.9%) (8–11).