Loss or functional inactivation of NF2 or other upstream Hippo Pathway mediators lead to deregulation and deinhibition of YAP1 and NF2 mutant meningiomas and/or cell lines express high levels of YAP activity and upregulate the expression of several canonical YAP1 targets (such as CTGF and CYR61) (14, 20, 21). The gene discussed is YAP1; the disease is meningioma.