The most common mutations (based on a targeted sequencing panel) were found in NF2, BRCA1, RGPD3, APC, TSC1, KDM6A, and SMARCE1; however, other mutations frequently found in adult meningiomas (TRAF7, KLF4, AKT1, SMO, and TERT) were either significantly underrepresented (TRAF7; 1 out of 34 tumors) or completely absent. This evidence concerns the gene AKT1 and meningioma.