Among other targets, this leads to the transcriptional activation of fibroblast growth factor 3 (FGF3) expression in KLF4-K409Q-expressing cells, not present in wild-type KLF4-expressing cells, and KLF4-K409Q-mutated meningiomas expressed higher levels of FGF3 compared to KLF4-wild-type tumors (37). The gene discussed is KLF4; the disease is meningioma.