Loss or functional inactivation of NF2 or other upstream Hippo Pathway mediators lead to deregulation and deinhibition of YAP1 and NF2 mutant meningiomas and/or cell lines express high levels of YAP activity and upregulate the expression of several canonical YAP1 targets (such as CTGF and CYR61) (14, 20, 21). This evidence concerns the gene NF2 and meningioma.