Furthermore, the expression of a non-regulatable YAP1 variant (S127/397A-YAP1) induces very similar transcriptional changes compared to NF2 loss in human neural stem cells, and that the expression of the same construct in Nestin-positive cells in the meninges of Cdkn2a null mice induces the formation of meningioma-like tumors that resemble human NF2 mutant meningiomas by histomorphology and gene expression (14). Here, NES is linked to meningioma.